Sleep Balance Profile

The industry’s most accurate sleep-wake cycle testing reveals whether hormones are your hidden barrier to restful sleep. Measures cortisol and melatonin in dried urine at 4 time points – providing a true 24-hour sleep-wake pattern. Melatonin, a hormone produced by the pineal gland during the dark phase of the light/dark cycle, regulates the sleep/wake cycle and the “biological clock”. However, it is now known also to have free radical scavenging and antioxidant properties and a significant role in stimulating the immune system to protect against the growth of abnormal tissues such as breast and prostate cancers.

The Sleep Balance Profile:  Accurate, Affordable, Accessible

Now a simple - at home- option eliminates the need for middle of the night samples. The first morning MT6s represents night time melatonin production.  Collecting four dried urine strips at four time points during the day is easy and convenient.

Sleep Balance Profile



  Includes:  In Dried Urine: Melatonin (MTgsx4) Free Cortisol (C x 4)

The graph shows the typical circadian variation in urinary melatonin and cortisol levels (ZRT data).

Melatonin production is greatest during the nighttime hours, resulting in a peak urinary MT6s early in the morning. Melatonin is gradually suppressed during daylight hours and rises during the evening towards bedtime.

In an opposing pattern, night-time cortisol production is at its lowest; it is normally at its highest immediately after waking, peaking in the urine around 2 hours later. Cortisol levels drop towards the end of the day, with progressively lower levels in the evening as the night-time nadir is approached.

 Summary: Uncover the truth about sleepless nights.  Restful sleep depends upon several key hormones being in balance.  Now a simple - at home- option eliminates the need for middle of the night samples. The first four-point test profile offering a complete diurnal pattern of melatonin and cortisol.

Price: $219.00


Self Assessment for Men Self Assessment for Women Order Test

Adequate melatonin production during the night, as well as suppression of production during the day by exposure to daylight, form a balance that is vital to optimal health. Circulating melatonin is rapidly and efficiently hydroxylated and conjugated with sulfate in the liver to form its primary metabolite, 6-sulfatoxymelatonin (MT6s), and excreted into urine; it is this metabolite that is measured in the Sleep Balance Profile.

Cortisol, a hormone produced by the adrenal glands in response to stress, is also known for its diurnal variation linked to the sleep/wake cycle.

It has the opposite pattern to melatonin production in a healthy individual. While melatonin rises at night to peak during the early hours of the morning, cortisol is at its lowest levels throughout the night. After waking, melatonin production dips with the onset of daylight and cortisol rises and peaks about 30 minutes to 1 hour after rising. Cortisol production falls gradually during the day, while melatonin begins to rise during the evening as daylight diminishes, and the cycle repeats itself. When the cortisol pattern is disrupted, for example as a result of excessive stressors, this can lead to high night cortisol, disrupted sleeping patterns, and exposure to more night time light, which in turn leads to lowered levels of melatonin.

Knowledge is the key to wellness

The lab will email you when your results are ready, generally 3-5 business days after samples are received by the lab.  

  • You will receive information on how to access your results on-line. 
  • Consider consulting with a practitioner for next steps.
  • Knowledge is the key to wellness.

Find out what you need to know and start your path towards recovery today.



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The Canary Club is an educational advisory group with a team of medical advisors headed by Richard Shames, M.D.