With 20+ years of experience and results from over 8 million tests, ZRT Laboratory is a recognized leader in innovative, safe, and meaningful hormone and wellness testing. Individuals, health care providers in all 50 states and 96 countries, and research teams worldwide use our tests, including the Centers for Disease Control and Prevention, the National Institutes of Health and many renowned universities.
Overall assessment of male health and vitality. 23 tests in blood spot.
The Wellness Metrics Profile identifies specific imbalances of one or more hormones that govern key aspects of our health, contributing to immunity, mood changes, energy, libido, altered metabolism, increased body fat deposition, and food/sugar cravings, and includes tests identifying increased risks for cardiometabolic disease and diabetes.
- LCMS7 Hormones (saliva)
- Thyroid Hormones (blood spot)
- Cardiometabolic and Vitamin D
Our broadest view of sex steroid hormone metabolite levels and cortisol metabolism with full diurnal melatonin and BPA. 44 tests
ZRT Laboratory now offers a comprehensive LC-MS/MS saliva assay that measures the levels of 23 endogenous steroid hormones, including estrogens, progestogens, androgens, glucocorticoids, and mineralocorticoids.
In addition to endogenous hormones, the new assay quantifies
How it helps:
By mapping the full steroid hormone cascade, this profile provides deep insights into hormone balance, enzyme function, and potential effects of both natural and pharmaceutical inhibitors, helping guide personalized clinical decisions.
This profile is designed to reveal how your major hormone systems interact, helping practitioners identify patterns, not just isolated numbers.
Comprehensive hormone panel that measures 14 hormones, secosteroids, and enzymes to assess the health of your thyroid, adrenal, and gonadal endocrine glands, along with vitamin D2 and vitamin D3.
Designed especially for men, this is an overall assessment of male hormonal status, vitality, and performance. Tests four glands: thyroid, adrenals, testes, and prostate. 15 tests. (B-202, B-220, S-141)
Overall assessment of female health and vitality in blood spot. 12 Tests in dried blood spot only.
Overall assessment of male health and vitality in blood spot. 14 tests in blood spot only. Includes: E1, E2, E3 Pg (Progesterone), T (Testosterone), DS (DHEA-S), C (Cortisol), SHBG (Sex Hormone Binding Globulin), PSA (Prostate-Specific Antigen), and thyroid: TSH (Thyroid-Stimulating Hormone), FT3 (Free T3), FT4 (Free T4), TPOab (Thyroid Peroxidase Antibodies), TT4, TgB (B243 202)
Hormones keeping you up? Find out with the 24-hour Sleep Balance Profile.
Reveals if your hormones are blocking your sleep.
The Sleep Balance Profile measures cortisol and melatonin 4 times in 24 hours to map your true sleep-wake rhythm.
"Is it hormones? Now you’ll know."
Like hormones, neurotransmitters depend on precise balance. Even subtle shifts can significantly affect brain activity. potentially leading to overstimulation or understimulation. These imbalances may influence mood, stress response, focus, and overall neurological health.
Gain a deeper understanding of your brain chemistry with this advanced profile. It measures 26 key neurotransmitters—along with the proteins and metabolites that support them—to provide a comprehensive view of your brain and nervous system function.
Foggy and unfocused? Identify the cause—fix the problem.
Add-ons: A variety of optional add-on tests are available to provide even more insight. See each add-on for specific details.
Comprehensive evaluation focusing exclusively on estrogen metabolites.
This profile consists of 12 tests that precisely measure levels of estrone (E1), estradiol (E2), and estriol (E3), while also assessing your body's efficiency in processing and breaking down and metabolizing estrogen-related hormones.
Basic male hormone and adrenal health, and prostate monitoring. 8 tests in an all-in-one, easy-to-use at-home hormone test kit with dried blood spot.
Vitality Core includes E2 (Estradiol), E1 (Estrone), Pg (Progesterone), T (Testosterone), DS (DHEA-S), C (Cortisol), SHBG (Sex Hormone Binding Globulin), PSA (Prostate-Specific Antigen) (B-202 242)
S-142 | LCMS Hormones 7 with 4-point Cortisol (lab name)
10 total tests measuring 7 hormones.
This at-home saliva panel measures Estradiol (E2), Estrone (E1), Estriol (E3) Progesterone (Pg), Testosterone (T), and DHEA-S (DS) once each, plus Cortisol at 4 timepoints in one day (4 tests) to show your daily cortisol pattern. Cortisol naturally changes across the day, so a 4-point series can add context vs. a single sample.
Good fit if you want clear data—especially with fatigue, sleep problems, mood changes, cycle changes, or low libido.
Tests Estradiol (E2), Progesterone (Pg), and Testosterone (T). SHBG in blood spot. (B-240
Heavy Metals and Essential Elements Test Kit
ZRT Comprehensive Toxic & Essential Elements Profile measures 14 of the most common toxic heavy metals: and essential elements.
This profile measures 7 key hormones in saliva using the highly precise LC-MS method, available for both females and males: (S-125)
Why it matters: LC-MS provides a detailed view of the full steroid hormone cascade, offering deeper insight into clinical issues that may arise from insufficient or excessive hormone therapies.
Measuring levels of toxic metals and essential elements can help determine if there are deficiencies or toxicity affecting the thyroid gland. This comprehensive test measures 14 levels of hormones, toxicity, and essential elements.
The thyroid gland can be affected by factors like nutritional deficiencies and environmental exposure to toxic elements. This profile can evaluate elemental exposure, thyroid hormone synthesis, and some causes of thyroid disorders and other health issues.
ZRT CardioMetabolic Profile measures (in blood spot): (B-222)
Insulin, High Sensitivity C-Reactive Protein (hsCRP), Glycated Hemoglobin (hbA1C), Triglyceride (TG), Total Cholesterol (CH), High-density lipoprotein (HDL), low-density lipoprotein (LDL), Very-low-density lipoprotein (VLDL)
Allows early detection of major indicators associated with metabolic/insulin resistance syndrome. Used as a screening profile to reduce the overall risk of type 2 diabetes and cardiovascular disease (CVD).
Cortisol Awakening Response (CAR) Test (S-122)
The CAR test provides detailed insights into adrenal function and helps identify conditions linked to abnormal cortisol levels.
Collect six saliva samples in a single day from the comfort of your home, then mail to a CLIA-certified lab for analysis.
How it works:
Morning response: Capture the first three samples within the first hour after waking.
Your results reveal your body’s full cortisol pattern, helping guide personalized health strategies.
5 total tests measuring 5 hormones.
This at-home saliva panel checks two key hormone systems that work together every day: your reproductive hormones and your adrenal stress hormones. It measures Estradiol (E2), Progesterone (Pg), Testosterone (T), and DHEA-S (DS) once each (4 tests), plus Cortisol (C) as a single sample (1 test). Together, these results help you see how these hormones are showing up as a group, and how the signals may be balancing against each other—think of it like a three-legged stool where stability depends on the legs working together.
A strong choice if you want a clean starting point to understand your hormone picture—especially with low energy, sleep disruption, mood shifts, cycle changes, or changes in libido.
This profile measures your full daily cortisol cycle (Diurnal Cortisol 4x) plus DHEA-S, a key adrenal hormone.
Together, these results provide a comprehensive view of adrenal function and overall stress response.
Tests only Estradiol (E2), Progesterone (Pg), and Testosterone (T). Good for a simple low-cost re-test of these hormones. In saliva.
Blood Spot Thyroids: Six clinically useful thyroid markers in one blood-spot test—more context than TSH alone. Checks TSH, FT4, FT3, TT4, Tgbn (thyroglobulin), and TPOab (TPO antibodies) for a broader snapshot of thyroid function.
Measure your body’s cortisol pattern across the day with four saliva samples collected at key times. This test provides insights into adrenal function and helps identify abnormal cortisol levels that may impact energy, stress, and sleep.
How it works:
Blood spot only. Measures the toxic and essential elements: Zn: Zinc, Cu: Copper, Cadmium, Mg: Magnesium, Se: Selenium, and Hg: Mercury. This test does NOT include iodine, bromine, arsenic, or creatinine.
This test measures both essential and toxic elements, so it could be considered for evaluating the body's elemental status. It can help identify potential heavy metal toxicity or deficiencies in essential minerals.
Measures the essential nutrients iodine, selenium, lithium, and bromine, plus the toxic heavy metals arsenic, cadmium, and mercury and the waste by-product creatinine. Dried urine only (no blood spot).
ZRT Vitamin D Sunshine Profile includes (in blood spot):
25-OH D2, 25-OH D3, Total Vitamin D (Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D3)
Vitamin D deficiency can lead to hypertension, joint pain, muscle weakness, and even heart disease and stroke. This test measures both the biologically active (D3) and supplemented (D2) forms.
Up to 10% of the population in the U.S. has iodine deficiency. Iodine is essential in healthy thyroid hormone production, brain function, breast tissue, fetal development and more.
Prostate-specific antigen (PSA), is a protein produced by the male prostate gland. It is an important indicator of prostate health.
This single test is taken from a blood spot sample.
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The Canary Club is an educational advisory group with a team of medical advisors headed by Richard Shames, M.D.
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