With 20+ years of experience and results from over 8 million tests, ZRT Laboratory is a recognized leader in innovative, safe, and meaningful hormone and wellness testing. Individuals, health care providers in all 50 states and 96 countries, and research teams worldwide use our tests, including the Centers for Disease Control and Prevention, the National Institutes of Health and many renowned universities.
Overall assessment of male health and vitality. 23 tests in blood spot.
Our broadest view of sex steroid hormone metabolite levels and cortisol metabolism with full diurnal melatonin and BPA. 44 tests
The Wellness Metrics Profile identifies specific imbalances of one or more hormones that govern key aspects of our health, contributing to immunity, mood changes, energy, libido, altered metabolism, increased body fat deposition, and food/sugar cravings, and includes tests identifying increased risks for cardiometabolic disease and diabetes.
- LCMS7 Hormones (saliva)
- Thyroid Hormones (blood spot)
- Cardiometabolic and Vitamin D
This profile is designed to reveal how your major hormone systems interact, helping practitioners identify patterns, not just isolated numbers.
Comprehensive hormone panel that measures 14 hormones, secosteroids, and enzymes to assess the health of your thyroid, adrenal, and gonadal endocrine glands, along with vitamin D2 and vitamin D3.
Designed especially for men, this is an overall assessment of male hormonal status, vitality, and performance. Tests four glands: thyroid, adrenals, testes, and prostate. 15 tests. (B-202, B-220, S-141)
ZRT Laboratory now offers a comprehensive LC-MS/MS saliva assay that measures the levels of 23 endogenous steroid hormones, including estrogens, progestogens, androgens, glucocorticoids, and mineralocorticoids.
In addition to endogenous hormones, the new assay quantifies
How it helps:
By mapping the full steroid hormone cascade, this profile provides deep insights into hormone balance, enzyme function, and potential effects of both natural and pharmaceutical inhibitors, helping guide personalized clinical decisions.
Overall assessment of male health and vitality in blood spot. 14 tests in blood spot only. Includes: E1, E2, E3 Pg (Progesterone), T (Testosterone), DS (DHEA-S), C (Cortisol), SHBG (Sex Hormone Binding Globulin), PSA (Prostate-Specific Antigen), and thyroid: TSH (Thyroid-Stimulating Hormone), FT3 (Free T3), FT4 (Free T4), TPOab (Thyroid Peroxidase Antibodies), TT4, TgB (B243 202)
Starts at $299. Every option combines 7 saliva hormones with dried-urine neurotransmitter-related markers.
Choose the Core profile, add more detail about daily stress and sleep patterns, or choose a 4-point saliva cortisol to see how cortisol changes across the day.
Sleep disruption plus a persistent “wired,” keyed-up, or stress-reactive feeling?
The Sleep Balance Profile Plus measures cortisol, cortisone, the melatonin metabolite MT6s, norepinephrine, and epinephrine across four timed dried urine samples collected during one day.
It provides the complete Sleep Balance circadian assessment while adding four-point catecholamine measurements for a broader view of sympathetic and adrenal stress-response activity.
Explore your daily cortisol pattern alongside neurotransmitter-related markers. The CC NT + Calm Focused Profile combines 4-point saliva cortisol with a dried-urine neurotransmitter panel in one profile.
Bring both sets of results to a conversation with your clinician about stress, mood, sleep, energy, and focus. Collect saliva and dried-urine samples at home using the kit instructions.
Overall assessment of female health and vitality in blood spot. 12 tests in dried blood spot only.
Hormones keeping you up? Find out with the 24-hour Sleep Balance Profile.
Reveals if your hormones are blocking your sleep.
The Sleep Balance Profile measures cortisol and melatonin 4 times in 24 hours to map your true sleep-wake rhythm.
"Is it hormones? Now you’ll know."
Comprehensive evaluation focusing exclusively on estrogen metabolites.
This profile consists of 12 tests that precisely measure levels of estrone (E1), estradiol (E2), and estriol (E3), while also assessing your body's efficiency in processing and breaking down and metabolizing estrogen-related hormones.
U-325 | LCMS Neurotransmitters (lab name)
Measures dried-urine neurotransmitter-related markers and metabolites for practitioner review of patterns associated with mood, focus, motivation, sleep, and stress response. Optional add-ons provide cortisol, sleep-stress rhythm, or hormone context.
Basic male hormone and adrenal health, and prostate monitoring. 8 tests in an all-in-one, easy-to-use at-home hormone test kit with dried blood spot.
Vitality Core includes E2 (Estradiol), E1 (Estrone), Pg (Progesterone), T (Testosterone), DS (DHEA-S), C (Cortisol), SHBG (Sex Hormone Binding Globulin), PSA (Prostate-Specific Antigen) (B-202 242)
S-142 | LCMS Hormones 7 with 4-point Cortisol (lab name)
10 total tests measuring 7 hormones.
This at-home saliva panel measures Estradiol (E2), Estrone (E1), Estriol (E3) Progesterone (Pg), Testosterone (T), and DHEA-S (DS) once each, plus Cortisol at 4 timepoints in one day (4 tests) to show your daily cortisol pattern. Cortisol naturally changes across the day, so a 4-point series can add context vs. a single sample.
Good fit if you want clear data—especially with fatigue, sleep problems, mood changes, cycle changes, or low libido.
This profile measures 7 key hormones in saliva using the highly precise LC-MS method, available for both females and males: (S-125)
Why it matters: LC-MS provides a detailed view of the full steroid hormone cascade, offering deeper insight into clinical issues that may arise from insufficient or excessive hormone therapies.
Tests estradiol (E2), progesterone (Pg), and testosterone (T). SHBG in blood spot. (B-240
ZRT CardioMetabolic Profile measures (in blood spot): (B-222)
Insulin, High Sensitivity C-Reactive Protein (hsCRP), Glycated Hemoglobin (hbA1C), Triglyceride (TG), Total Cholesterol (CH), High-density lipoprotein (HDL), low-density lipoprotein (LDL), Very-low-density lipoprotein (VLDL)
Allows early detection of major indicators associated with metabolic/insulin resistance syndrome. Used as a screening profile to reduce the overall risk of type 2 diabetes and cardiovascular disease (CVD).
Measuring levels of toxic metals and essential elements can help determine if there are deficiencies or toxicity affecting the thyroid gland. This comprehensive test measures 14 levels of hormones, toxicity, and essential elements.
The thyroid gland can be affected by factors like nutritional deficiencies and environmental exposure to toxic elements. This profile can evaluate elemental exposure, thyroid hormone synthesis, and some causes of thyroid disorders and other health issues.
Heavy Metals and Essential Elements Test Kit
ZRT Comprehensive Toxic & Essential Elements Profile measures 14 of the most common toxic heavy metals and essential elements.
Cortisol Awakening Response (CAR) Test (S-122)
The CAR test provides detailed insights into adrenal function and helps identify conditions linked to abnormal cortisol levels.
Collect six saliva samples in a single day from the comfort of your home, then mail to a CLIA-certified lab for analysis.
How it works:
Morning response: Capture the first three samples within the first hour after waking.
Your results reveal your body’s full cortisol pattern, helping guide personalized health strategies.
5 total tests measuring 5 hormones.
This at-home saliva panel checks two key hormone systems that work together every day: your reproductive hormones and your adrenal stress hormones. It measures Estradiol (E2), Progesterone (Pg), Testosterone (T), and DHEA-S (DS) once each (4 tests), plus Cortisol (C) as a single sample (1 test). Together, these results help you see how these hormones are showing up as a group, and how the signals may be balancing against each other—think of it like a three-legged stool where stability depends on the legs working together.
A strong choice if you want a clean starting point to understand your hormone picture—especially with low energy, sleep disruption, mood shifts, cycle changes, or changes in libido.
Tests only Estradiol (E2), Progesterone (Pg), and Testosterone (T). Good for a simple low-cost re-test of these hormones. In saliva.
This profile measures your full daily cortisol cycle (Diurnal Cortisol 4x) plus DHEA-S, a key adrenal hormone.
Together, these results provide a comprehensive view of adrenal function and overall stress response.
Measure your body’s cortisol pattern across the day with four saliva samples collected at key times. This test provides insights into adrenal function and helps identify abnormal cortisol levels that may impact energy, stress, and sleep.
How it works:
Blood Spot Thyroids: Six clinically useful thyroid markers in one blood spot test—more context than TSH alone. Checks TSH, FT4, FT3, TT4, Tgbn (thyroglobulin), and TPOab (TPO antibodies) for a broader snapshot of thyroid function.
Blood spot only. Measures the toxic and essential elements: Zn: Zinc, Cu: Copper, Cadmium, Mg: Magnesium, Se: Selenium, and Hg: Mercury. This test does NOT include iodine, bromine, arsenic, or creatinine.
This test measures both essential and toxic elements, so it could be considered for evaluating the body's elemental status. It can help identify potential heavy metal toxicity or deficiencies in essential minerals.
Measures the essential nutrients iodine, selenium, lithium, and bromine, plus the toxic heavy metals arsenic, cadmium, and mercury and the waste by-product creatinine. Dried urine only (no blood spot).
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The Canary Club is an educational advisory group with a team of medical advisors headed by Richard Shames, M.D.
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